ArticlePeerJ2026
Identification of key circadian rhythm-associated genes as differentially expressed genes for cytomegalovirus infection in very-low-birth-weight infants.
Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Human cytomegalovirus (HCMV) infection has adverse effects on very low-birth-weight infants (VLBW) and is complicated with liver dysfunction, thrombocytopenia, and hearing impairment. Therefore, we explored new potential intervention targets in VLBW infants with HCMV infection. Methods: Enrichment analysis of adult HCMV infection and control groups was performed in the GSE81246 dataset. Peripheral blood mononuclear cells (PBMCs) from VLBW infants with HCMV and those without HCMV ( Results: The key circadian rhythm genes PER1 and CRY1 were screened. RT-qPCR was used to detect PER1 and CRY1 mRNA levels in the PBMCs of VLBW infants with HCMV ( Conclusion: PER1 and CRY1 mRNA was significantly decreased in PBMCs from HCMV infected VLBW infants, providing new ideas for studying potential effective therapeutic targets for HCMV infection in VLBW infants.
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