ArticleBone reports2026
Transferrin-dependent uptake and distribution of iron in osteoclast-like cells.
Article in Bone reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Iron is an essential micro component and is involved in numerous critical cellular processes and in energy production. While its roles in oxygen transport and in oxidative phosphorylation are well documented, it remains to be elucidated, whether iron modulates specific cellular processes in different organs. Iron deficiency has been found to lead to a decrease in the capacity of osteoclasts to dissolve amorphous calcium phosphate. Furthermore, levels of iron in the cellular environment led to significant changes in the levels of transcripts encoding iron transport proteins. Within the present study, the uptake of iron by osteoclasts and the kinetics of intracellular transport were analyzed. For this purpose, M-CSF (Macrophage-Colony Stimulating Factor) dependent non-adherent osteoclast progenitor cells were differentiated to osteoclasts in media containing M-CSF and RANKL (Receptor Activator of NF-κB Ligand). For the upregulation of iron transport capacity, media were supplemented with Deferoxamine, an iron complexor, rendering the cultures virtually iron-free. To analyze iron uptake by osteoclast like cells, holo-transferrin, loaded with
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