Evidence map›Paper›PMID 41800109›Full record

ArticleMediators of inflammation2026

The Mediating Factor of Immune Cell in the Causal Relationship Between Cardiovascular Disease-Related Plasma Proteins and Parkinson's Disease: A Network Mendelian Randomization Analysis.

Ruotong Yao, Siyao Chen, Yangguang Lu, Yiquan Li, Bohuai Yu, Yingying Liu, Tingxuan Zhang, Yusheng Zhu, Feng Chen, Yuhan Lin and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ruotong YaoDepartment of Neurology, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, 150 Ximen Road Linhai City, Taizhou, Zhejiang, China, wmu.edu.cn.ORCID https://orcid.org/0009-0009-0748-6756
Siyao ChenDepartment of Neurology, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, 150 Ximen Road Linhai City, Taizhou, Zhejiang, China, wmu.edu.cn.
Yangguang LuDepartment of Neurology, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, 150 Ximen Road Linhai City, Taizhou, Zhejiang, China, wmu.edu.cn.ORCID https://orcid.org/0009-0005-5327-3963
Yiquan LiDepartment of Neurology, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, 150 Ximen Road Linhai City, Taizhou, Zhejiang, China, wmu.edu.cn.
Bohuai YuThe First School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, China, wmu.edu.cn.
Yingying LiuThe First School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, China, wmu.edu.cn.
Tingxuan ZhangRenji College, Wenzhou Medical University, Wenzhou, Zhejiang, China, wmu.edu.cn.
Yusheng ZhuThe Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China, wmu.edu.cn.
Feng ChenThe Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China, wmu.edu.cn.
Yuhan LinThe First School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, China, wmu.edu.cn.
Yukai WangThe Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China, wmu.edu.cn.
Cai LiDepartment of Neurology, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, 150 Ximen Road Linhai City, Taizhou, Zhejiang, China, wmu.edu.cn.ORCID https://orcid.org/0009-0009-9345-2156

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cardiovascular diseases (CVDs) and their associated plasma proteins exhibit significant correlations with immunity and Parkinson's disease (PD). However, the specific contributions to the risk of developing PD remain unclear. This study aims to investigate the potential causal relationship between CVD-related plasma proteins and the risk of PD and explore the significant mediating role of immune cell phenotypes. Methods: Using publicly available genetic data, we conducted Mendelian randomization (MR) analysis using the inverse variance weighting method to explore the causal relationship between 83 CVD-related plasma proteins and PD. Various MR analysis models were employed for sensitivity analysis. Concurrently, we utilized bioinformatics methods such as protein-protein interaction networks and pathway enrichment analysis to investigate the potential associations between CVD-related plasma proteins and PD-related genes. Finally, we employed a mediator MR design to identify the mediating effects of 731 immune cell phenotypes in the onset of PD. Results: Elevated levels of Fas cell surface death receptors ( Conclusions: Our study elucidates the close genetic association between CVD-related plasma proteins and PD and identifies the significant mediating role of immune cells, thereby providing valuable insights for future research and clinical applications.

Indexed as

Blood ProteinsCardiovascular DiseasesMendelian Randomization AnalysisParkinson DiseaseHumansNerve Growth FactorProtein Interaction MapsRisk FactorsBlood ProteinsNerve Growth Factorcardiovascular diseaseimmune phenotypeMendelian randomizationParkinson’s disease

Identifiers

PMID41800109
PMCPMC12960748

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.