ArticleFrontiers in pharmacology2026
Anjiang formula inhibits PVN microglial activation and lowers blood pressure by targeting RhoA/ROCK2 pathway: a retrospective clinical and experimental study.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Neuroinflammation in the hypothalamic paraventricular nucleus (PVN) drives sympathetic overactivity in hypertension. The Anjiang Formula (AJ) shows clinical antihypertensive potential; however, the precise molecular targets mediating its central neuroprotective effects remain undefined. Methods: In this translational study, we investigated the clinical efficacy of AJ and tested the hypothesis that it directly inhibits the central RhoA/ROCK2 signaling axis. We integrated a retrospective cohort analysis with mechanistic validation. Clinically, 85 elderly patients with Grade 1 essential hypertension were treated with AJ ( Results: Clinically, AJ reduced systolic blood pressure (SBP) by a mean difference of 10.2 mmHg compared to controls ( Conclusion: AJ provides antihypertensive efficacy in elderly patients. These benefits are mechanistically driven by Shinflavanone-mediated inhibition of ROCK2, which attenuates central neuroinflammation and restores redox homeostasis in the PVN.
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