Evidence map›Paper›PMID 41799996›Full record

ArticleInternational journal of clinical pediatric dentistry2026

Comparative Evaluation of Salivary Nitric Oxide in Caries-free and Affected Children before and after Total Oral Rehabilitation.

Krishna Priya, Swagata Saha, Kavita Rai, Prajna P Nayak, Manju R Nair, Prajna Bhandary, Sharmila Kameyanda Poonacha, Nishi Joshi, Aishani Baksi

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Article in International journal of clinical pediatric dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Krishna PriyaDepartment of Pediatric and Preventive Dentistry, A B Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University), Mangaluru, Karnataka, India.ORCID https://orcid.org/0009-0003-8939-2329
Swagata SahaDepartment of Pediatric and Preventive Dentistry, Dr D Y Patil Dental College and Hospital, Pune, Maharashtra, India.ORCID https://orcid.org/0000-0002-2343-5977
Kavita RaiDepartment of Pediatric and Preventive Dentistry, A B Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University), Mangaluru, Karnataka, India.ORCID https://orcid.org/0000-0002-9677-4144
Prajna P NayakDepartment of Pediatric and Preventive Dentistry, A B Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University), Mangaluru, Karnataka, India.ORCID https://orcid.org/0000-0001-8872-860X
Manju R NairDepartment of Pediatric and Preventive Dentistry, A B Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University), Mangaluru, Karnataka, India.ORCID https://orcid.org/0000-0002-9391-6223
Prajna BhandaryDepartment of Central Research Laboratory, KS Hegde Medical Academy, NITTE (Deemed to be University), Mangaluru, Karnataka, India.ORCID https://orcid.org/0000-0002-3268-6743
Sharmila Kameyanda PoonachaDepartment of Central Research Laboratory, KS Hegde Medical Academy, NITTE (Deemed to be University), Mangaluru, Karnataka, India.ORCID https://orcid.org/0000-0002-1604-2120
Nishi JoshiDepartment of Pediatric and Preventive Dentistry, A B Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University), Mangaluru, Karnataka, India.ORCID https://orcid.org/0009-0004-0381-1586
Aishani BaksiDepartment of Pediatric and Preventive Dentistry, A B Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University), Mangaluru, Karnataka, India.ORCID https://orcid.org/0000-0002-7279-7827

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Early childhood caries (ECC) is a multifactorial disease and a major public health concern. Saliva, a noninvasive diagnostic medium, plays a vital role in oral health. Nitric oxide (NO), beyond its physiological functions, exhibits potent antimicrobial properties and may serve as a biomarker for caries activity. Aim: To estimate salivary NO levels in children with ECC and severe ECC (S-ECC) before and after total oral rehabilitation. Design: Sixty-six physically and mentally healthy children aged 3-5 years were categorized into three groups: group I (caries-free), group II (ECC), and group III (S-ECC). Salivary NO and dietary nitrate were assessed at baseline. Groups II and III were reassessed at 1 week and 3 months postrehabilitation. Results: Baseline salivary NO and dietary nitrate levels were significantly higher in the caries-free group ( Conclusion: Higher NO levels in caries-free children and postrehabilitation increase in NO suggest its potential as a prognostic biomarker. How to cite this article: Priya K, Saha S, Rai K,

Indexed as

BiomarkersEarly childhood cariesNitric oxideSalivaSalivary nitric oxide

Identifiers

PMID41799996
PMCPMC12964423

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