ArticleRSC advances2026
A chitosan-based thermosensitive hydrogel incorporating propranolol nanoparticles to promote early osseointegration and peri-implant soft-tissue healing.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Based on clinical evidence that propranolol enhances bone mineral density, improves early implant stability, and promotes soft-tissue healing, this study investigated whether its local application around dental implants could coordinately promote early osseointegration and gingival tissue repair. To enable localized drug delivery while minimizing systemic adverse effects such as hypotension associated with oral administration, a chitosan-based thermosensitive hydrogel incorporating propranolol-loaded nanospheres was developed and systematically characterized. Cell models related to osseointegration and gingival healing, including MC3T3-E1, Hacats, and HGFs, were used for
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