ArticleFrontiers in neuroscience2026
Glymphatic system dysfunction in temporal lobe epilepsy with hippocampal sclerosis: MRI-based evaluation of circulatory markers and disease progression.
Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Reduced BOLD-CSF coupling as a potential functional imaging correlate of semantic fluency decline in MRI-negative temporal lobe epilepsy.Frontiers in aging neuroscience · 2026Article
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10 authors.
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Abstract
Objectives: In this study, several MRI-derived glymphatic markers were utilized to evaluate alterations in glymphatic system (GS) function in patients with temporal lobe epilepsy and hippocampal sclerosis (TLE-HS). Methods: we assessed 160 participants, including 80 patients with TLE-HS and 80 healthy controls (HCs). Glymphatic circulation was evaluated using MRI-based markers, including choroid plexus volume (CPV), perivascular space (PVS) volume, the fraction of white matter free water (FW-WM), and diffusion tensor imaging along the perivascular space (DTI-ALPS) index. Group differences were evaluated using two-sample tests, and associations were assessed using partial Spearman's rank correlations (ρ). Results: In patients with TLE-HS, the DTI-ALPS index ( Conclusion: This study offers substantiated evidence of GS function in patients with TLE-HS using multiple MRI-derived indices of GS function. Moreover, longer disease duration was significantly associated with lower DTI-ALPS indices, higher FW-WM levels, and enlarged CPV, while reduced HPV was closely linked to decreased DTI-ALPS and increased CPV. These findings indicate that MRI-derived GS indices may serve as potential imaging biomarkers of disease chronicity in TLE-HS.
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