Evidence map›Paper›PMID 41799882›Full record

ArticleFrontiers in neuroscience2026

Analysis of NDNF and SLC1A2 gene expression in the dorsolateral prefrontal cortex of individuals with autism.

Ariel Moraes de Andrade, Larysy Raquelly Vidal de Souza, Rodrigo Freire Oliveira, Karina Maia Paiva, Felipe Porto Fiuza, Pedro Henrique Silva de Farias, Roque Ribeiro da Silva Júnior, Maria Vanessa Freitas Holanda, Thales Allyrio Araújo de Medeiros Fernandes, Paulo Leonardo Araújo de Góis Morais and 1 more

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Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ariel Moraes de AndradeLaboratory of Experimental Neurology, Department of Biomedical Health, State University of Rio Grande do Norte, Mossoró, Brazil.
Larysy Raquelly Vidal de SouzaAna Bezerra University Hospital (HUAB/EBSERH/UFRN), Santa Cruz, RN, Brazil.
Rodrigo Freire OliveiraLaboratory of Experimental Neurology, Department of Biomedical Health, State University of Rio Grande do Norte, Mossoró, Brazil.
Karina Maia PaivaLaboratory of Experimental Neurology, Department of Biomedical Health, State University of Rio Grande do Norte, Mossoró, Brazil.
Felipe Porto FiuzaPostgraduate Program in Neuroengineering, Edmond and Lily Safra International Institute of Neurosciences, Santos Dumont Institute, Macaíba, Brazil.
Pedro Henrique Silva de FariasAna Bezerra University Hospital (HUAB/EBSERH/UFRN), Santa Cruz, RN, Brazil.
Roque Ribeiro da Silva JúniorLaboratory of Biochemistry and Molecular Biology, Department of Biomedical Health, State University of Rio Grande do Norte, Mossoró, Brazil.
Maria Vanessa Freitas HolandaLaboratory of Experimental Neurology, Department of Biomedical Health, State University of Rio Grande do Norte, Mossoró, Brazil.
Thales Allyrio Araújo de Medeiros FernandesLaboratory of Biochemistry and Molecular Biology, Department of Biomedical Health, State University of Rio Grande do Norte, Mossoró, Brazil.
Paulo Leonardo Araújo de Góis MoraisLaboratory of Experimental Neurology, Department of Biomedical Health, State University of Rio Grande do Norte, Mossoró, Brazil.
José Rodolfo Lopes de Paiva CavalcantiLaboratory of Experimental Neurology, Department of Biomedical Health, State University of Rio Grande do Norte, Mossoró, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This study investigated the expression of NDNF and SLC1A2 in the dorsolateral prefrontal cortex of individuals with Autism Spectrum Disorder (ASD), a region linked to executive functions, emotional regulation, social skills, and sensory processing. Methods: Using data from the Allen Human Brain Atlas - Autism Study, 17 post-mortem cases (ASD: 9; controls: 8; ages 2-14) were analyzed with Results: No significant differences in NDNF expression were observed, though a trend toward lower levels in ASD was noted. In contrast, SLC1A2 expression was significantly increased in ASD and showed age-related growth, possibly reflecting neuroinflammatory processes. Nissl staining indicated similar neuronal density between groups, suggesting that gene expression changes may reflect functional alterations rather than cell number. Conclusion: These results highlight complex neurogenesis alterations in ASD and underscore the need for further research to identify biomarkers and potential therapeutic targets.

Indexed as

Autism Spectrum Disorderdorsolateral prefrontal cortexgene expressionNDNFSLC1A2 (EAAT2)

Identifiers

PMID41799882
PMCPMC12961583

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