Evidence map›Paper›PMID 41799861›Full record

ArticleBrain communications2026

Hippocampal morphometry is altered in infants with congenital heart disease.

Barat Gal-Er, Alexandra F Bonthrone, Emily S Nichols, Andrew T M Chew, Daniel Cromb, Chiara Casella, Alexia Egloff, Kuberan Pushparajah, John Simpson, Mary A Rutherford and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Barat Gal-ErCentre for the Developing Brain, Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.ORCID https://orcid.org/0009-0007-9419-8853
Alexandra F BonthroneCentre for the Developing Brain, Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.
Emily S NicholsDepartment of Applied Psychology, Faculty of Education, Western University, London, Ontario, Canada N6G 1G7.
Andrew T M ChewCentre for the Developing Brain, Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.
Daniel CrombCentre for the Developing Brain, Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.ORCID https://orcid.org/0000-0002-9814-8841
Chiara CasellaCentre for the Developing Brain, Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.ORCID https://orcid.org/0000-0002-0292-3330
Alexia EgloffCentre for the Developing Brain, Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.
Kuberan PushparajahDepartment of Cardiovascular Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.
John SimpsonDepartment of Cardiovascular Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.
Mary A RutherfordCentre for the Developing Brain, Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.
A David EdwardsCentre for the Developing Brain, Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.ORCID https://orcid.org/0000-0003-4801-7066
Joseph V HajnalCentre for the Developing Brain, Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.
Chiara NosartiCentre for the Developing Brain, Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.ORCID https://orcid.org/0000-0001-6305-9710
Jonathan O'MuircheartaighCentre for the Developing Brain, Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.ORCID https://orcid.org/0000-0002-8033-6959
Emma G DuerdenDepartment of Applied Psychology, Faculty of Education, Western University, London, Ontario, Canada N6G 1G7.ORCID https://orcid.org/0000-0002-9734-7865
Serena J CounsellCentre for the Developing Brain, Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.ORCID https://orcid.org/0000-0002-8033-5673

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital heart disease (CHD) is associated with impaired early brain development and an increased risk of adverse neurodevelopmental outcomes. Previous studies have reported smaller hippocampal volumes in infants, children and adolescents with CHD. However, it is unclear whether specific subfields are differentially sensitive as hippocampal subfield morphometry has not been assessed in this population. The aims of this study were to test the hypothesis that infants with CHD deviate from typical hippocampal morphometry, using a normative modelling approach with reference data from 217 typically developing infants, and characterize the relationship between hippocampal morphometric measures and both cerebral oxygen delivery and neurodevelopmental outcomes in infants with CHD. Infants with CHD [60 preoperative and 29 postoperative, gestational age at birth median (range) 38.43 (36.71-40.57) weeks, postmenstrual age at scan 39.86 (37.14-45.71) weeks] and typically developing infants underwent brain MRI on a 3T scanner, and T

Indexed as

cerebral oxygen deliverycongenital heart diseasehippocampusmorphometryMRI

Identifiers

PMID41799861
PMCPMC12965832

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.