Evidence map›Paper›PMID 41799812›Full record

Trial reportFrontiers in psychiatry2026

Olink proteomics identifies FGF-19 as a treatment-responsive inflammatory biomarker associated with acupuncture intervention in young females with mild depression.

Zhongxian Li, Zitong Jiao, Min Peng, Pan Zhang, Haiyan Xu, Ruiming Chen, Qiaoyu Ji, Jingjing Li, Lihua Chen, Beibei Zhao and 2 more

Abstract readClinical Trial
In one paragraph

Trial report in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhongxian Li *Department of Acupuncture and Moxibustion, Shenzhen Bao'an District Traditional Chinese Medicine Hospital, Shenzhen, China.
Zitong Jiao *Department of Acupuncture and Moxibustion, Shenzhen Bao'an District Traditional Chinese Medicine Hospital, Shenzhen, China.
Min PengDepartment of Acupuncture and Moxibustion, Shenzhen Bao'an District Traditional Chinese Medicine Hospital, Shenzhen, China.
Pan ZhangDepartment of Acupuncture and Moxibustion, Shenzhen Bao'an District Traditional Chinese Medicine Hospital, Shenzhen, China.
Haiyan XuDepartment of Acupuncture and Moxibustion, Shenzhen Bao'an District Traditional Chinese Medicine Hospital, Shenzhen, China.
Ruiming ChenDepartment of Acupuncture and Moxibustion, Shenzhen Bao'an District Traditional Chinese Medicine Hospital, Shenzhen, China.
Qiaoyu JiDepartment of Acupuncture and Moxibustion, Shenzhen Bao'an District Traditional Chinese Medicine Hospital, Shenzhen, China.
Jingjing LiDepartment of Acupuncture and Moxibustion, Shenzhen Bao'an District Traditional Chinese Medicine Hospital, Shenzhen, China.
Lihua ChenDepartment of Acupuncture and Moxibustion, Shenzhen Bao'an District Traditional Chinese Medicine Hospital, Shenzhen, China.
Beibei ZhaoDepartment of Acupuncture and Moxibustion, Shenzhen Bao'an District Traditional Chinese Medicine Hospital, Shenzhen, China.
Wenbin FuGuangzhou University of Chinese Medicine, Guangzhou, China.
Peng ZhouDepartment of Acupuncture and Moxibustion, Shenzhen Bao'an District Traditional Chinese Medicine Hospital, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mild depression in women is a distinct disorder with unclear immune mechanisms. This study aims to identify peripheral inflammatory biomarkers and to explore acupuncture's immunomodulatory effects via Olink proteomics. Thirty female participants (18-45 years) were assigned to healthy controls (HC), mild depression (MD), and acupuncture treatment (ACU). Plasma samples were analyzed using the Olink Clinical Trial Registration: https://www.chictr.org.cn/showprojEN.html?proj=189355, identifier ChiCTR2300068054.

Indexed as

acupunctureFGF-19inflammatory biomarkersmild depressionolinkproteomics

Identifiers

PMID41799812
PMCPMC12960610

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.