ArticleOphthalmology science2026
Geographic Atrophy on Fundus Autofluorescence and Color Fundus Photographs: Association with Deep Visual Sensitivity Losses.
Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
23 authors.
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Abstract
Purpose: To determine the functional characteristics of color fundus photograph (CFP)- and fundus autofluorescence (FAF)-defined geographic atrophy (GA) lesions by evaluating the prevalence of repeatable deep visual sensitivity defects. Design: Reader study. Participants: One hundred seventy-one pairs of CFP and FAF images from 60 eyes of 53 individuals. Methods: High-density, targeted microperimetry testing (with Goldmann Size III stimuli) was performed twice per visit in a 3.5° (approximately 1000 μm) diameter region of interest with retinal pigment epithelium and outer retinal atrophy on OCT imaging. Twelve readers from 6 established reading centers assessed CFP and FAF images within these regions sampled on microperimetry for GA, and performed annotations where GA was deemed to be present. Geographic atrophy on CFP was defined as a well-demarcated, roughly round or oval region of hypopigmentation, separately with and without requiring increased visibility of the underlying choroidal vessels (referred to as CFP-defined GA Main Outcome Measures: Prevalence of a repeatable ≤10 dB defect for CFP- and FAF-defined GA ≥175 μm, and the minimum lesion size showing a ≥90% prevalence of a repeatable ≤10 dB defect (deemed characteristic of regions with a truly nonresponding test location on microperimetry). Results: Color fundus photograph-defined GA Conclusions: Color fundus photograph and FAF-defined GA lesions ≥175 μm do not show the same functional characteristics as regions with a truly nonresponding test location, and only much larger lesions (approximately ≥650 μm) showed such similar functional characteristics. These findings provide crucial insights when considering CFP- and FAF-defined atrophic endpoints for clinical studies. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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