Evidence map›Paper›PMID 41799777›Full record

ArticleInternational journal of medical sciences2026

Narciclasine triggers apoptosis in osteosarcoma cells via JNK-mediated extrinsic and intrinsic pathways.

Jia-Sin Yang, Chia-Hsuan Chou, Pei-Ni Chen, Yi-Hsien Hsieh, Chih-Hsin Tang, Shun-Fa Yang, Ko-Hsiu Lu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jia-Sin YangDepartment of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
Chia-Hsuan ChouDepartment of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
Pei-Ni ChenDepartment of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
Yi-Hsien HsiehDepartment of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
Chih-Hsin TangDepartment of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan.
Shun-Fa YangDepartment of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
Ko-Hsiu LuDepartment of Orthopedics, Chung Shan Medical University Hospital, Taichung, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteosarcoma, the most prevalent bone cancer in teenagers, constitutes 3-5% of pediatric cancers and carries a poor prognosis due to its high metastatic potential. Although narciclasine induces apoptosis in various cancers, its effects on human osteosarcoma cells remain unclear. This study investigated the apoptotic impact of narciclasine on U2OS and HOS osteosarcoma cells. It was found that narciclasine induces dose-dependent apoptosis and sub-G

Indexed as

Amaryllidaceae AlkaloidsBone NeoplasmsOsteosarcomaPhenanthridinesApoptosisCell Line, TumorGene Expression Regulation, NeoplasticHumansInhibitor of Apoptosis ProteinsJNK Mitogen-Activated Protein KinasesMAP Kinase Signaling SystemSurvivinAmaryllidaceae AlkaloidsInhibitor of Apoptosis ProteinsJNK Mitogen-Activated Protein KinasesnarciclasinePhenanthridinesSurvivinapoptosiscaspaseJNK pathwaynarciclasineosteosarcoma

Identifiers

PMID41799777
PMCPMC12965065

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.