ReviewInternational journal of medical sciences2026
Dual Role of Transcription Factors in the Development and Thermogenic Function of Brown Adipose Tissue.
Review in International journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Phytochemicals and Irisin as Multi-Target Regulators of Adipose Tissue Browning and Metabolic Reprogramming: Synergies with GLP-1 Pathways.Antioxidants (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity, a major global health challenge, is intricately linked to various metabolic disorders, primarily driven by an imbalance between energy intake and expenditure. Brown adipose tissue (BAT), through its unique thermogenic capability, dissipates energy as heat, playing a vital role in regulating energy homeostasis and maintaining body temperature. Recent studies have revealed a complex regulatory network involving multiple transcription factors (e.g., PPARγ, EBF2, ZFP516, FOXP1) and signaling pathways (e.g., cAMP-PKA, AMPK, mTOR), which act synergistically to finely tune the development and thermogenic function of BAT. Furthermore, gene therapy based on adeno-associated virus (AAV) vectors, which enhances the thermogenic capacity of BAT, provides a highly promising strategy for addressing obesity and metabolic disorders. Additionally, several natural product extracts including
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Registered trials
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