ArticleBiochemistry and biophysics reports2026
Investigating the consequences of tape-stripping in ovalbumin-induced allergic mouse model: From physiology to gene regulation.
Article in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Food allergy is a growing global health concern, with increasing prevalence and significant impacts on patients quality of life. Epithelial barrier dysfunction, particularly through the skin-gut axis, has emerged as a critical factor in food allergy pathogenesis. However, the precise mechanisms linking epithelial barrier disruption to immune dysregulation remain poorly understood. This study investigates the effects of tape-stripping-induced epithelial barrier damage on the exacerbation of ovalbumin (OVA)-induced food allergy in a murine model, with a focus on histopathological, immunological, and transcriptomic changes. Methods: Female BALB/c mice were randomly assigned to three experimental groups for comparison: Control, OVA (OVA-sensitized/challenged), and OVA + T (OVA-sensitized/challenged with additional tape-stripping). Mice in the OVA group were sensitized and challenged with ovalbumin, while the OVA + T group underwent the same OVA protocol plus repeated tape-stripping to simulate epithelial barrier disruption. Allergic responses were evaluated using a comprehensive approach, including histopathological analysis, quantification of serum biomarkers (IgE, histamine, IL-6, IgG1), immune cell profiling via flow cytometry, and Western blot analysis of tight junction proteins such as occludin, Zonula Occludens (ZO)-1, and claudin. RNA sequencing-based transcriptomic analysis of jejunum tissues identified dysregulated pathways through integrated bioinformatics analyses (differential expression, pathway enrichment, and PPI network), with subsequent qRT-PCR validation pinpointing key target genes. Results: Tape-stripping exacerbated allergic symptoms, including diarrhea and elevated rectal temperature, and induced significant histopathological changes in both skin and intestinal tissues, characterized by increased inflammatory cell infiltration and mast cell accumulation. Serum analysis revealed elevated levels of IgE, histamine, IL-6, and IgG1, indicating a heightened allergic state. Flow cytometry demonstrated an increase in CD4 Conclusion: This study demonstrates that tape-stripping exacerbates food allergy by disrupting epithelial barrier integrity, inducing systemic immune dysregulation, and altering gene expression in intestinal tissues. The identification of key molecular pathways and target genes-particularly
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