ArticleAnnals of gastroenterological surgery2026
Impact of Renin-Angiotensin System Inhibitors on Renal Function During Temporary Ileostomy Period in Rectal Cancer Patients: A Retrospective Cohort Study.
Article in Annals of gastroenterological surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study aims to elucidate the effects of renin-angiotensin system inhibitors (RASIs) on renal function throughout the stoma period in patients undergoing ileostomy formation and subsequent stoma closure following rectal cancer surgery. Methods: In this single-center retrospective study, patients who underwent rectal resection with temporary ileostomy between January 2010 and December 2020 were divided into two groups based on RASI use. Renal function was assessed using the estimated glomerular filtration rate (eGFR) at pre-surgery (T0), a month post-surgery (T1), and pre-stoma closure (T2). The eGFR, its change at each point, and the chronic kidney disease (CKD) classification were used to assess early and subsequent changes in renal function. Results: Nineteen of 101 patients were using RASI. The RASI and control groups both exhibited eGFR decline at T1, with the former group showing a significantly lower median eGFR (56.2 mL/min/1.73m Conclusion: Our findings suggest that the use of RASIs is associated with early perioperative renal function impairment in patients undergoing ileostomy and stoma closure, with relatively slow recovery. These results indicate the impact of RASIs on eGFR and the importance of careful renal function management.
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