Evidence map›Paper›PMID 41799501›Full record

ArticleOncology research2026

Effect of Photosensitiser Chlorin E6 on Cancerous Bone Tumor Cells Using Photodynamic Therapy.

Frank Traub, Muhammad A Panezai, Michaela Moisch, Julia Melke, Leonard Schöbel, Tilmann Busse, Fei Xing, Jiachen Sun, Ulrike Ritz

Abstract read
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In one paragraph

Article in Oncology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Frank TraubDepartment of Orthopaedics and Traumatology, Biomatics Group, Institute for Immunology and Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg University, Langenbeckstr. 1, Mainz, 55131, Germany.
Muhammad A PanezaiDepartment of Orthopaedics and Traumatology, Biomatics Group, Institute for Immunology and Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg University, Langenbeckstr. 1, Mainz, 55131, Germany.
Michaela MoischDepartment of Orthopaedics and Traumatology, Biomatics Group, Institute for Immunology and Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg University, Langenbeckstr. 1, Mainz, 55131, Germany.
Julia MelkeDepartment of Orthopaedics and Traumatology, Biomatics Group, Institute for Immunology and Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg University, Langenbeckstr. 1, Mainz, 55131, Germany.
Leonard SchöbelDepartment of Orthopaedics and Traumatology, Biomatics Group, Institute for Immunology and Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg University, Langenbeckstr. 1, Mainz, 55131, Germany.
Tilmann BusseDepartment of Orthopaedics and Traumatology, Biomatics Group, Institute for Immunology and Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg University, Langenbeckstr. 1, Mainz, 55131, Germany.
Fei XingDepartment of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China.
Jiachen SunDepartment of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China.
Ulrike RitzDepartment of Orthopaedics and Traumatology, Biomatics Group, Institute for Immunology and Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg University, Langenbeckstr. 1, Mainz, 55131, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Photodynamic therapy (PDT) is a minimally invasive method used in the treatment of various cancers and skin diseases, but it is not widely used in bone cancer, where the current therapy is often not effective and accompanied by side effects. Alternative and more effective therapies like PDT are needed. In this Methods: A total of 27 tissue specimens from patients with primary bone cancers or bone metastases of different origins were genetically characterized and treated with PDT. Following a 24-h incubation, cell viability was determined, and the effect of PDT on cell migration was analyzed over 48 h. Results: We could demonstrate that the effect on proliferation of PDT in combination with the PS Ce6 was best in cells isolated from primary osteosarcoma and in bone metastases from mammary carcinomas. Besides proliferation, PDT was also effective in inhibiting the migration of these cells. A statistically significant correlation between the PDT effect and CD164 gene expression was detected, indicating that a high expression of this gene could result in a higher effectiveness of the photodynamic treatment. Conclusion: This study analyzes for the first time the effect of PDT in bone cancers and metastases and shows the potential of treating these cancer types with Ce6 PDT.

Indexed as

Bone NeoplasmsOsteosarcomaPhotochemotherapyPhotosensitizing AgentsPorphyrinsCell Line, TumorCell MovementCell ProliferationCell SurvivalChlorophyllidesFemaleHumansChlorophyllidesPhotosensitizing AgentsphytochlorinPorphyrinsbone cancerbone metastasisChlorin e6Cluster of Differentiation 164Photodynamic therapyphotosensitizer

Identifiers

PMID41799501
PMCPMC12963686

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.