ArticleClinical interventions in aging2026
Development and Validation of a Prognostic Model for One-year Mortality in Older Adults with Acute Myocardial Infarction Incorporating Activities of Daily Living Impairment.
Article in Clinical interventions in aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Purpose: Functional impairment, measured by Activities of Daily Living (ADL), is a major predictor of poor outcomes in older adults. However, among patients with acute myocardial infarction (AMI), a prognostic model that incorporates ADL status is lacking. This study aimed to develop and validate such a model for predicting one-year mortality in older adults with AMI. Patients and Methods: This study included 43,308 AMI patients admitted to the Tianjin Health and Medical Big Data Superplatform from January 2010 to March 2024. Patients were categorized by Barthel Index into ADL normal (n=41,312), mildly impaired ADL (n=1,318), moderately impaired ADL (n=452), and severely impaired ADL (n=226). The cohort was randomly split 7:3 for model development and validation. A nomogram for 1-year all-cause mortality was constructed using predictors identified by Lasso regression, with model performance evaluated through receiver operating characteristic curve (ROC), decision curve analysis (DCA), and calibration curve. Results: Baseline characteristics revealed that with increasing ADL impairment, patients were significantly older [median (IQR): 73·0 (68·0-78·0) vs 78·0 (73·0-83·0) vs 79·0 (73·0-84·0) vs 78·0 (73·0-83·0), Conclusion: We developed and validated a clinically applicable nomogram for predicting one-year mortality in older adults with AMI, integrating ADL impairment into risk assessment. Incorporating functional evaluation into prognostic modeling may improve individualized management and early rehabilitation planning in geriatric cardiology.
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