Evidence map›Paper›PMID 41799361›Full record

ArticleKidney international reports2026

Proximal Tubule Reabsorption and CKD Progression in the General Population.

Marius Øvrehus, Jesse Ikeme, Ronit Katz, Knut A Langlo, Yngvar Haaskjold, Michael G Shlipak, Joachim H Ix, Stein Hallan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marius ØvrehusDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Jesse IkemeDepartment of Medicine, Kidney Health Research Collaborative of San Francisco, San Francisco Veterans Affairs Healthcare System and University of California San Francisco, San Francisco, California, USA.
Ronit KatzDepartment of Obstetrics & Gynecology, University of Washington, Seattle, Washington, USA.
Knut A LangloDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Yngvar HaaskjoldDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Michael G ShlipakDepartment of Medicine, Kidney Health Research Collaborative of San Francisco, San Francisco Veterans Affairs Healthcare System and University of California San Francisco, San Francisco, California, USA.
Joachim H IxDivision of Nephrology-Hypertension, Department of Medicine, University of California San Diego.
Stein HallanDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Current markers of chronic kidney disease (CKD) primarily reflect kidney glomerular health and do not include markers of kidney tubule health. Methods: We used a case-cohort design with 1246 adults randomly sampled from the general population-based Trøndelag health study (HUNT)-3 study (Norway, 2006-2008) and 445 cases experiencing major adverse kidney events (MAKE; progressive CKD [ Results: At baseline, mean age was 53 years (SD: 15), eGFR was 92 ml/min per 1.73 m Conclusion: The proximal tubule reabsorption markers, urine A1M and B2M, were associated with MAKE beyond eGFR, albuminuria, and CKD risk factors. Assessing tubule health may improve CKD staging and risk stratification.

Indexed as

alpha-1-microglobulinbiomarkerchronic kidney diseasegeneral populationprogressiontubule functions

Identifiers

PMID41799361
PMCPMC12966674

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.