Evidence map›Paper›PMID 41799291›Full record

ArticleACG case reports journal2026

Upadacitinib for the Treatment of Cutaneous Crohn's Disease Presenting as Lymphangioma Circumscriptum.

Benjamin Gerstein, William C Lau, Avi Bitterman, Jonas A Adalsteinsson, Zoe Gottlieb, Rachel Kassenoff, Ahuva Cices

Abstract readCase Reports
In one paragraph

Article in ACG case reports journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Benjamin GersteinKimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY.ORCID https://orcid.org/0009-0006-7750-5957
William C LauKimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY.
Avi BittermanKimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY.
Jonas A AdalsteinssonKimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY.
Zoe GottliebDr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Rachel KassenoffDepartment of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, NY.
Ahuva CicesKimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metastatic Crohn's disease refers to cutaneous Crohn's disease noncontiguous with the gastrointestinal tract. Vulvar lymphangioma circumscriptum is a rare manifestation of metastatic Crohn's disease, presenting as pink papillomatous or vesicular papules and plaques. Treatment options are limited and often invasive, and clearance is difficult to achieve. We report a novel case of vulvar lymphangioma circumscriptum secondary to Crohn's disease successfully managed with oral and topical Janus kinase inhibitors in combination with procedural therapies.

Indexed as

Crohn's diseaseJAK inhibitorlymphangioma circumscriptummetastatic cutaneous Crohn's diseaseUpadacitinib

Identifiers

PMID41799291
PMCPMC12965969

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.