Evidence map›Paper›PMID 41799208›Full record

ArticleTheranostics2026

Bimetallic Cu/Fe-MOF-based heterojunction sonozymes for triple amplification of sono-immunotherapy through activating tumor-specific cuproptosis and cGAS-STING pathway.

Xueyuan Liu, Nan Wang, Jinming Cai, Jinyan Hu, Zhenlin Zhang, Chuanqi Feng, Dengyu Pan, Bijiang Geng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xueyuan LiuSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China.
Nan WangSenior Department of Obstetrics and Gynecology, Chinese PLA General Hospital, Beijing 100007, China.
Jinming CaiSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China.
Jinyan HuSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China.
Zhenlin ZhangSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China.
Chuanqi FengShandong Provincial Key Laboratory of Monocrystalline Silicon Semiconductor Materials and Technology, College of Chemistry and Chemical Engineering, Dezhou University, Dezhou, Shandong 253023, China.
Dengyu PanSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China.
Bijiang GengSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Initiating ROS-induced ICD and activating innate immune pathways are promising strategies for reprogramming immunosuppressive TME and eliciting persistent antitumor immune responses. Methods: To realize the cascade amplification of antitumor immune response, we report for the first time a TME-responsive nanoplatform through coating oxygen-vacancy-doped MnO Results: The reversal of the immunosuppressive tumor microenvironment occurs through the ROS-triggered ICD and the enhancement of DC cell maturation. More importantly, the activation of the Mn ions-mediated cGAS-STING pathway further boosts the maturation of DCs. In addition, the released Cu ions can induce cuproptosis, achieving triple amplification of antitumor immune response. Conclusion: The combination therapy of CDT, SDT, cuproptosis, and cGAS-STING activation via FCMM, achieved complete elimination of primary tumor and significant controlled the growth of distant tumor. This work combines sonocatalytic nanomedicine with immune modulation strategy through integrating ROS amplification, cGAS-STING activation, and cuproptosis effect into a single nanoplatform, providing new insights for the clinical application of sono-immunotherapy.

Indexed as

CopperImmunotherapyMembrane ProteinsNucleotidyltransferasesAnimalsCell Line, TumorcGAS-STING Signaling PathwayCuproptosisCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDendritic CellsHumansIronManganese CompoundsMiceReactive Oxygen SpeciesSTING ProteincGAS protein, humanCopperCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseIronManganese CompoundsMembrane ProteinsNucleotidyltransferasesReactive Oxygen SpeciesSTING ProteincGAS-STING activationCu dopingFe-based metal-organic frameworksoxygen-vacancy-doped MnO2-xsono-immunotherapy

Identifiers

PMID41799208
PMCPMC12964376

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.