Evidence map›Paper›PMID 41799184›Full record

ReviewTheranostics2026

Recent advances of metal-organic frameworks (MOFs) for drug delivery, cancer imaging and theranostics.

Honglian Yu, Gan Lin, Peng Mi

Abstract readReview
In one paragraph

Review in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Honglian YuDepartment of Radiology and State Key Laboratory of Biotherapy, West China Hospital, and College of Polymer Science and Engineering, Sichuan University, No.17 South Renmin Road, Chengdu, Sichuan 610041, China.
Gan LinDepartment of Biomedical Engineering, NanoSTAR Institute, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Peng MiDepartment of Radiology and State Key Laboratory of Biotherapy, West China Hospital, and College of Polymer Science and Engineering, Sichuan University, No.17 South Renmin Road, Chengdu, Sichuan 610041, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metal-organic frameworks (MOFs) are a unique class of porous materials constructed from metal-containing nodes, known as secondary building units (SBUs) and organic ligands. Their highly tunable structures enable the encapsulation of a broad range of therapeutic agents, spanning small-molecule chemotherapeutics to biomacromolecules such as proteins, DNA, and RNA. By rational selection of metal ions and organic linkers, diverse functionalities, including molecular imaging and phototherapeutic capabilities, can be included into MOFs, rendering them promising nanoscale platforms of nanomedicines. In this review, we summarize recent advances of MOFs for drug delivery, cancer imaging and theranostics. We discuss the progress in regulating the morphology and functions of MOFs through diverse synthetic strategies and surface modification approaches. We further systematically analyzed and discussed MOFs in the applications of drug delivery, molecular imaging, and cancer theranostics, with recent strategies. Finally, key limitations associated with the clinical translation of MOFs are discussed, along with the corresponding bottlenecks, future challenges, and emerging opportunities.

Indexed as

Drug Delivery SystemsMetal-Organic FrameworksMolecular ImagingNeoplasmsTheranostic NanomedicineAnimalsAntineoplastic AgentsHumansAntineoplastic AgentsMetal-Organic Frameworksdrug deliverymetal-organic frameworksmolecular imaging.nanocarrierstheranostics

Identifiers

PMID41799184
PMCPMC12964380

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.