ArticleJournal of medical biochemistry2025
Investigating the causal association between plasma lipids and the risk of squamous cervical cancer: A two-sample mendelian randomization study.
Article in Journal of medical biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Background: This study aimed to investigate the causal relationship between plasma lipid levels-total cholesterol (TC), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C)and the risk of squamous cervical cancer (SCC) using Mendelian Randomization (MR). Methods: Genome-wide association study (GWAS) data for plasma lipid traits were obtained from the Global Lipids Genetics Consortium (GLGC), and SCC outcome data were sourced from the FinnGen consortium. The primary analysis was conducted using the inverse variance weighted (IVW) method, supported by Mr-Egger regression, weighted median, and weighted mode approaches. Sensitivity analyses were performed to assess the robustness of the results, and the Steiger test was used to evaluate the directionality of the associations. Results: The IVW analysis revealed that higher plasma levels of TC (OR: 1.777; 95% CI: 1.118-2.825; p = 0.015) and LDL-C (OR: 1.674; 95% CI: 1.013-2.767; p = 0.044) were associated with an increased risk of SCC. No significant associations were found between TGs (OR: 0.644; 95% CI: 0.343-1.212; p = 0.173) or HDL-C (OR: 1.050; 95% CI: 0.616-1.790; p = 0.857) and SCC. Conclusions: This study provides evidence of a causal relationship between elevated plasma TC and LDL-C levels and a higher risk of SCC, highlighting a novel aspect of SCC etiology. These findings may inform further functional and clinical research in the progression of SCC.
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