ArticleJournal of medical biochemistry2025
Association of miR-223-3p and miR-223-5p gene expression with levels of IgE, vitamin D and Mg+2 in pediatric asthma patients.
Article in Journal of medical biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Asthma, a global non-communicable disease, significantly impacts public health. Severe cases cause high morbidity and mortality rates, with childhood asthma rates in Iraq reaching 20%. The study investigated the expression levels of miR-223-3p and miR-223-5p genes linked to pediatric asthma and the impact of IgE, Vitamin D, and Mg+2 on asthma severity. Methods: A study of 140 children aged 1-10 years with allergic asthma was conducted in Baghdad from November 2023 to February 2024. The patients were divided into three groups: those under 1, those aged 1-5, and those over 5. Serum IgE, Vit D3, and Mg+2 levels were determined using the Immunoglobulin E Test Kit. Results: The results indicated a significant increase in the level of IgE in patients (353.812 ± 2 5 .679 ng/mL) compared to the control group (25.320± 2.581 ng/mL) (pvalue < 0.01, the serum level of Vit-D revealed a significant decrease in the patient group (16 .9 0 7 ± 0 .5 1 2 ng/mL) while in the control group, levels reached (32.746± 1.629 ng/mL), Mg+2 serum level decreased in patient groups (2 .1 6 8 ± 0 .0 3 0 ng/dL) compared to control group (2 .316± 0.028 ng/dL) at p-value < 0.01. also, this study shows that upregulation of gene expression in miR-223-3p and miR-223-5p genes are considered risk factors for allergic asthma. Conclusions: The study found that asthma patients had high IgE levels, low vitamin D3 and magnesium levels, and high gene expression in miR-223-3p and miR-223-5p genes, risk factors for allergic asthma.
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