Evidence map›Paper›PMID 41799150›Full record

ArticleACS omega2026

Synthesis and Pharmacological Evaluation of Novel 1,5-Disubstituted-3-amino-1,2,4-triazoles Designed as Multitarget Directed Ligands for Alzheimer's Disease Targets.

Daiana Portella Franco, Lucas Caruso, Danniel Cosme Neves Grillo, Nathália Fonseca Nadur, Luciana Luiz de Azevedo, Thiago Moreira Pereira, Manuelle Cunha da Silva, Renata Barbosa Lacerda, Pedro de Sena Murteira Pinheiro, Cristiano Jorge Riger and 1 more

Abstract read
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In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Daiana Portella FrancoLaboratory of Molecular Diversity and Medicinal Chemistry (LaDMol-QM), Department of Organic Chemistry, Institute of Chemistry, Federal Rural University of Rio de Janeiro, Seropédica 23897-000, Rio de Janeiro, Brazil.
Lucas CarusoLaboratory of Molecular Diversity and Medicinal Chemistry (LaDMol-QM), Department of Organic Chemistry, Institute of Chemistry, Federal Rural University of Rio de Janeiro, Seropédica 23897-000, Rio de Janeiro, Brazil.
Danniel Cosme Neves GrilloLaboratory of Oxidative Stress in Microorganisms, Department of Biochemistry, Institute of Chemistry, Federal Rural University of Rio de Janeiro, Seropédica 23897-000, Rio de Janeiro, Brazil.
Nathália Fonseca NadurLaboratory of Molecular Diversity and Medicinal Chemistry (LaDMol-QM), Department of Organic Chemistry, Institute of Chemistry, Federal Rural University of Rio de Janeiro, Seropédica 23897-000, Rio de Janeiro, Brazil.
Luciana Luiz de AzevedoLaboratory of Molecular Diversity and Medicinal Chemistry (LaDMol-QM), Department of Organic Chemistry, Institute of Chemistry, Federal Rural University of Rio de Janeiro, Seropédica 23897-000, Rio de Janeiro, Brazil.
Thiago Moreira PereiraLaboratory of Molecular Diversity and Medicinal Chemistry (LaDMol-QM), Department of Organic Chemistry, Institute of Chemistry, Federal Rural University of Rio de Janeiro, Seropédica 23897-000, Rio de Janeiro, Brazil.
Manuelle Cunha da SilvaLaboratory of Molecular Diversity and Medicinal Chemistry (LaDMol-QM), Department of Organic Chemistry, Institute of Chemistry, Federal Rural University of Rio de Janeiro, Seropédica 23897-000, Rio de Janeiro, Brazil.
Renata Barbosa LacerdaLaboratory of Molecular Diversity and Medicinal Chemistry (LaDMol-QM), Department of Organic Chemistry, Institute of Chemistry, Federal Rural University of Rio de Janeiro, Seropédica 23897-000, Rio de Janeiro, Brazil.
Pedro de Sena Murteira PinheiroLaboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio), Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, P.O. Box 68023, Rio de Janeiro 21941-902, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0003-4148-4243
Cristiano Jorge RigerLaboratory of Oxidative Stress in Microorganisms, Department of Biochemistry, Institute of Chemistry, Federal Rural University of Rio de Janeiro, Seropédica 23897-000, Rio de Janeiro, Brazil.
Arthur Eugen KümmerleLaboratory of Molecular Diversity and Medicinal Chemistry (LaDMol-QM), Department of Organic Chemistry, Institute of Chemistry, Federal Rural University of Rio de Janeiro, Seropédica 23897-000, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-8458-0975

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of 3-amino-1,2,4-triazole derivatives was synthesized and evaluated for their multitarget activities relevant to Alzheimer's disease. Inhibition assays revealed potent and preferential inhibition of acetylcholinesterase (AChE) for most of compounds, with IC

Identifiers

PMID41799150
PMCPMC12961494

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.