ArticleAnalytical science advances2026
Method Comparison of Dried Blood Spot and Plasma Apolipoprotein B Measurement on a Semi-Automated Analyser: Toward Accessible Lipid Profiling in Resource-Limited Settings.
Article in Analytical science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Apolipoprotein B (ApoB) is a key marker of atherogenic lipoprotein burden, but conventional plasma-based testing requires venous sampling and centralized laboratory infrastructure. Dried blood spot (DBS) sampling offers a minimally invasive alternative suitable for decentralized settings. This study evaluated the analytical performance of a DBS-based ApoB assay on the Chem7 semi-automated analyser and compared it with the Abbott ARCHITECT ci4100 plasma reference method. DBS samples prepared from 50 de-identified EDTA whole-blood specimens were extracted in saline and analysed using an immunoturbidimetric ApoB assay on the Chem7 analyser with a correction factor of 2 applied for haematocrit dilution. Paired plasma specimens were analysed on the ARCHITECT ci4100. Method comparison included Passing-Bablok and Deming regression and Bland-Altman analysis. Potential outliers were assessed using Grubbs' test (
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