ArticleTransplantation direct2026
Back-to-base Versus In-transit Machine Perfusion in Donation After Circulatory Death Liver Transplantation: Insights From a National Registry.
Article in Transplantation direct, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Machine-perfused Donation After Circulatory Death Grafts Improve Access to Liver Transplant for Primary Biliary Cholangitis Patients.Transplantation direct · 2026Article
- Comment on "Back-to-base Versus In-transit Machine Perfusion in Donation After Circulatory Death Liver Transplantation: Insights From a National Registry".Transplantation direct · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Normothermic machine perfusion (NMP) improves utilization of extended criteria liver grafts, but the optimal delivery strategy-whether in-transit or back-to-base-remains uncertain. Methods: Adult recipients of donation after circulatory death (DCD) liver transplants between January 1, 2022, and January 1, 2024, were identified using the national transplant database. In-transit NMP was defined as grafts coded as machine perfused; back-to-base NMP was inferred for noncoded grafts with a cold ischemia time of ≥10 h. Baseline characteristics, geographic distribution, and outcomes-including acute rejection, length of stay, and graft survival-were compared. Multivariable Cox regression was used to adjust for dialysis and recipient hospitalization status. A sensitivity analysis was performed, limited to cases with cold ischemia time of ≥10 h across both groups. Results: Among 1217 DCD liver transplants using NMP, 936 (77%) were in-transit and 281 (23%) were back-to-base. In-transit NMP was more commonly used in the Western United States, whereas back-to-base was concentrated in the Midwest and Southeast. In-transit recipients had higher rates of pretransplant dialysis (3.1% versus 0.7%; Conclusions: In-transit and back-to-base NMP strategies yield comparable clinical outcomes in DCD liver transplantation. Strategy selection may be guided by logistical infrastructure and center-level expertise without compromising recipient outcomes.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.