Evidence map›Paper›PMID 41799015›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2026

Immediate and Gradual Withdrawal of Immunosuppression After Kidney Graft Loss Lead to Similar Outcomes.

Asmaa Nabil, Nicolas Congy-Jolivet, Amandine Darres, Pierre Guy, Olivier Marion, Jean Milhes, Thomas Prudhomme, Nassim Kamar, Arnaud Del Bello

Abstract read
In one paragraph

Article in Transplant international : official journal of the European Society for Organ Transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Allograft nephrectomy: a systematic review of immunological consequences and management of immunosuppressants.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Asmaa NabilDepartment of Nephrology and Organ Transplantation, CHU de Toulouse, Toulouse, France.
Nicolas Congy-JolivetCentre Hospitalier et Universitaire, Université Paul Sabatier Toulouse III, Toulouse, France.
Amandine DarresDepartment of Nephrology and Organ Transplantation, CHU de Toulouse, Toulouse, France.
Pierre GuyDepartment of Nephrology and Organ Transplantation, CHU de Toulouse, Toulouse, France.
Olivier MarionDepartment of Nephrology and Organ Transplantation, CHU de Toulouse, Toulouse, France.
Jean MilhesLaboratory of Immunology, Biology Department, Centre Hospitalier et Universitaire (CHU) de Toulouse, Toulouse, France.
Thomas PrudhommeCentre Hospitalier et Universitaire, Université Paul Sabatier Toulouse III, Toulouse, France.
Nassim KamarDepartment of Nephrology and Organ Transplantation, CHU de Toulouse, Toulouse, France.
Arnaud Del BelloDepartment of Nephrology and Organ Transplantation, CHU de Toulouse, Toulouse, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The management of immunosuppression in dialysis patients with a failed kidney transplant remains a pending question, and different approaches to immunosuppression weaning have been proposed. We conducted a retrospective study of patients who experienced a graft failure, and compared the rates of immune and non-immune events, according to different modalities of immunosuppression withdrawal. Two hundred and eighteen patients were included. During the follow-up (45 (20-80) months post-graft failure), 53 patients (24.3%) experienced an intolerance syndrome. The time between graft failure and the occurrence of intolerance syndrome was 6 (3-13) months. Immunosuppression withdrawal was associated with the occurrence of intolerance syndrome. However, regarding the immunosuppression withdrawal modality, only a steroid cessation during the first 3 months post graft failure was independently associated with an earlier occurrence of intolerance syndrome [HR = 1.91, 95%CI (1.08-3.38),

Indexed as

Graft RejectionImmunosuppression TherapyImmunosuppressive AgentsKidney TransplantationAdultFemaleGraft SurvivalHumansMaleMiddle AgedRetrospective StudiesTime FactorsTreatment OutcomeImmunosuppressive Agentsallograft nephrectomyallo-sensitizationgraft failureimmunosuppressionintolerance syndrome

Identifiers

PMID41799015
PMCPMC12963015

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.