Evidence map›Paper›PMID 41798914›Full record

ArticleFrontiers in immunology2026

Immunopeptidomics of cutaneous leishmaniasis patients reveals the natural antigenic landscape.

Nicky de Vrij, Elise Pepermans, Louise Laurijssen, Thao-Thy Pham, Lauren Thijs, Kurt Boonen, Kadrie Ramadan, Ilse Maes, Yetemwork Aleka, Mekibib Kassa and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Nicky de VrijClinical Immunology Unit, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Elise PepermansCentre for Proteomics, University of Antwerp, Antwerp, Belgium.
Louise LaurijssenCentre for Proteomics, University of Antwerp, Antwerp, Belgium.
Thao-Thy PhamClinical Immunology Unit, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Lauren ThijsImmuneSpec, Niel, Belgium.
Kurt BoonenCentre for Proteomics, University of Antwerp, Antwerp, Belgium.
Kadrie RamadanClinical Reference Laboratory, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Ilse MaesMolecular Parasitology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Yetemwork AlekaLeishmaniasis Research and Treatment Centre, University of Gondar, Gondar, Ethiopia.
Mekibib KassaLeishmaniasis Research and Treatment Centre, University of Gondar, Gondar, Ethiopia.
Tigist MekonnenLeishmaniasis Research and Treatment Centre, University of Gondar, Gondar, Ethiopia.
Mezgebu Silamsaw AsresLeishmaniasis Research and Treatment Centre, University of Gondar, Gondar, Ethiopia.
Mikias WoldetensayDepartment of Dermatology and Venereology, University of Gondar, Gondar, Ethiopia.
Seid HassenBoru Meda Hospital, Dessie, Ethiopia.
Fentaw BialfewBoru Meda Hospital, Dessie, Ethiopia.
Feleke Tilahun ZewduBoru Meda Hospital, Dessie, Ethiopia.
Seid Getahun AbdelaBoru Meda Hospital, Dessie, Ethiopia.
Malgorzata Anna DomagalskaMolecular Parasitology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Bart CuypersAdrem Data Lab, Department of Computer Science, University of Antwerp, Antwerp, Belgium.
Saskia van HentenUnit of Neglected Tropical Diseases, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Johan van GriensvenUnit of Neglected Tropical Diseases, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Pieter MeysmanAdrem Data Lab, Department of Computer Science, University of Antwerp, Antwerp, Belgium.
Geert BaggermanCentre for Proteomics, University of Antwerp, Antwerp, Belgium.
Kris LaukensAdrem Data Lab, Department of Computer Science, University of Antwerp, Antwerp, Belgium.
Wim AdriaensenClinical Immunology Unit, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cutaneous leishmaniasis (CL) is a skin disease caused by Methods: To address this gap, we performed mass spectrometry-based immunopeptidomics on lesional biopsies from 27 Ethiopian CL patients spanning the full clinical spectrum. Results: We newly identified 333 MHC-I and 247 MHC-II epitopes from 398 Discussion: This first comprehensive map of the

Indexed as

Antigens, ProtozoanEpitopes, T-LymphocyteLeishmaniaLeishmaniasis, CutaneousAdultAntigen PresentationFemaleHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHumansMaleProteomicsAntigens, ProtozoanEpitopes, T-LymphocyteHistocompatibility Antigens Class IHistocompatibility Antigens Class IIantigen discoveryantigensEthiopiaimmunopeptidomicsLeishmanialeishmaniasisT cell epitopes

Identifiers

PMID41798914
PMCPMC12963358

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.