Evidence map›Paper›PMID 41798895›Full record

ArticleJournal of the Endocrine Society2026

Associations between maternal prepregnancy body mass index and maternal and cord blood metabolome.

Heidi Sormunen-Harju, Polina V Girchenko, Eero Kajantie, Pia M Villa, Esa K Hämäläinen, Emilia Huvinen, Marius Lahti-Pulkkinen, Hannele Laivuori, Katri Räikkönen, Saila B Koivusalo

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In one paragraph

Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Heidi Sormunen-HarjuTeratology Information Service, Emergency Medicine, Department of Prehospital Emergency Care, Helsinki University Hospital and University of Helsinki, Helsinki FI-00029, Finland.ORCID https://orcid.org/0000-0002-1038-4672
Polina V GirchenkoClinical Medicine Research Unit, MRC Oulu, University of Oulu, Oulu FI-90014, Finland.ORCID https://orcid.org/0000-0001-7185-2276
Eero KajantieClinical Medicine Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu FI-90014, Finland.ORCID https://orcid.org/0000-0001-7081-8391
Pia M VillaDepartment of Obstetrics and Gynecology, Helsinki University Hospital and University of Helsinki, Helsinki FI-00029, Finland.ORCID https://orcid.org/0000-0002-0317-0713
Esa K HämäläinenDepartment of Clinical Chemistry, University of Eastern Finland, Kuopio FI-70210, Finland.ORCID https://orcid.org/0000-0002-4614-4347
Emilia HuvinenDepartment of Obstetrics and Gynecology, Helsinki University Hospital and University of Helsinki, Helsinki FI-00029, Finland.ORCID https://orcid.org/0000-0003-2788-1947
Marius Lahti-PulkkinenDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki FI-00029, Finland.ORCID https://orcid.org/0000-0002-5244-5525
Hannele LaivuoriMedical and Clinical Genetics, Helsinki University Hospital and University of Helsinki, Helsinki FI-00029, Finland.ORCID https://orcid.org/0000-0003-3212-7826
Katri RäikkönenDepartment of Obstetrics and Gynecology, Helsinki University Hospital and University of Helsinki, Helsinki FI-00029, Finland.ORCID https://orcid.org/0000-0003-3124-3470
Saila B KoivusaloDepartment of Obstetrics and Gynecology, Helsinki University Hospital and University of Helsinki, Helsinki FI-00029, Finland.ORCID https://orcid.org/0000-0002-9482-9826

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Context: Prepregnancy body mass index (pBMI) is associated with the maternal metabolome during pregnancy. However, evidence remains inconclusive whether pBMI is also associated with alterations in the fetal cord blood metabolome, and whether pBMI modifies the associations between maternal and fetal metabolomes. Objective: This work aimed to examine whether pBMI is associated with the fetal cord blood metabolome and whether maternal and fetal metabolomes are associated and vary according to the degree of maternal pBMI. Methods: We derived pBMI from medical records and tested it in relation to 95 cord blood metabolic measures of 1702 newborns in the PREDO, RADIEL, and ITU studies. We tested the associations between maternal and fetal metabolomes and moderation by pBMI in 556 mother-child dyads of the PREDO and RADIEL studies contributing maternal blood samples at 3 time points during pregnancy. Results: In the meta-analysis of the 3 studies, higher pBMI was associated with 12 of the 95 cord blood metabolic measures, including lower levels of high-density lipoprotein-associated measures and higher levels of branched-chain and aromatic amino acids, as well as ketone bodies. Associations between maternal and fetal metabolomes were significant for 61 of the 95 measures; 26 of the 95 associations were modified by maternal pBMI, being stronger among mothers with obesity than those without. Conclusion: Maternal pBMI is associated with alterations in fetal cord blood metabolome. Maternal and fetal metabolomes are associated, and associations vary according to maternal pBMI.

Indexed as

body mass indexfetal bloodinfantmetabolomenewbornobesitypregnancy

Identifiers

PMID41798895
PMCPMC12964119

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.