Evidence map›Paper›PMID 41798846›Full record

ReviewFrontiers in nutrition2026

Plant-derived nutritional components in thyroid disease-related neuropsychiatric disorders: mechanistic insights and advances.

Zihan Zhang, Meng-Xiang Xu, Nana Wang, Ruilin Shen, Jiayu Sun, Min Zha, Meizi Wang

Abstract readReview
In one paragraph

Review in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zihan Zhang *Nanjing University of Chinese Medicine, Nanjing, China.
Meng-Xiang Xu *Mengcheng County Hospital of Traditional Chinese Medicine, Bozhou Second Chinese Medicine Hospital, Bozhou, China.
Nana Wang *Nanjing University of Chinese Medicine, Nanjing, China.
Ruilin ShenNanjing University of Chinese Medicine, Nanjing, China.
Jiayu SunNanjing University of Chinese Medicine, Nanjing, China.
Min ZhaNanjing University of Chinese Medicine, Nanjing, China.
Meizi WangNanjing University of Chinese Medicine, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plant-derived nutritional components represent a promising adjunctive strategy for addressing neuropsychiatric manifestations of thyroid disorders. Although conventional hormone replacement normalizes biochemical parameters, many patients continue to experience neurocognitive impairment and affective symptoms, underscoring the complexity of thyroid-brain axis regulation. This review synthesizes recent advances on how plant-based nutritional approaches may modulate oxidative stress, neuroinflammation, neurotransmitter homeostasis, and blood-brain barrier integrity, and evaluates their emerging clinical applicability and existing evidence gaps. Overall, plant-based interventions may complement standard therapy and improve neuropsychiatric outcomes, though larger prospective studies are needed to clarify their efficacy and identify suitable patient subgroups.

Indexed as

cognitive functionneuroinflammationoxidativestressplant-based nutritionthyroid–brain axis

Identifiers

PMID41798846
PMCPMC12960140

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.