ArticleFrontiers in nutrition2026
Association between vitamin D and serum uric acid in a large Chinese cohort of middle-aged and elderly Chinese men and women.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Vitamin D is essential for calcium homeostasis, bone health, and immune function, yet its association with serum uric acid (UA) remains uncertain. This study evaluates vitamin D status in Chinese adults and explores its sex- and age-specific relationships with UA and hyperuricemia (HUA). Methods: We conducted a cross-sectional analysis of 15,116 males and 25,895 females from The China Precision Nutrition and Health KAP Real World Study (CPNAS). Restricted cubic spline (RCS) visualized dose-response relationships, while multivariate regression assessed associations between vitamin D and UA/HUA. Subgroup analyses (age < 70 vs. ≥70, male vs. female) explored potential variations. Results: The study revealed a high prevalence of vitamin D deficiency (33.5%) and insufficiency (53%) in Chinese adults. Among males under 70 years, we observed an inverse J-shaped relationship between vitamin D and serum UA levels ( Conclusion: Vitamin D levels are differentially associated with UA and HUA based on sex and age, highlighting the need for personalized approaches in managing vitamin D and UA metabolism. Clinical trial registration: This trial was registered at https://www.chictr.org.cn/hvshowproject.html?id=178499&v=2.2, as ChiCTR2100051983.
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