ArticleFrontiers in neurology
Real-world data of opicapone in patients with Parkinson's disease experiencing motor fluctuations: the OPTIMO study.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Evaluate the outcomes of opicapone as an add-on treatment to levodopa/DDCI in patients with Parkinson's disease (PD) and motor fluctuations (MF) in a real-world setting. Methods: Observational, retrospective, and post-authorization study in patients with PD and MF treated with opicapone at 16 Spanish Movement Disorders centers. Results: Of 245 patients included (55.9% men; mean [standard deviation] age: 67.7 [10.4] years), 41.9 and 33.6% presented rigid-akinetic and tremor-dominant phenotypes, respectively; 43.8% had a history of dyskinesias. Patients started treatment with 50 mg/day opicapone 8.3 (5.3) years after diagnosis. At initiation, the mean levodopa dose was 620.7 (313.7) mg/day. According to the PGI-C (available in 178 patients), 74.2% of patients reported clinical improvement in MF, without worsening of dykinesias in 64.6%. Clinical improvement of MF with stable/improved dyskinesias was similar between PD phenotypes ( Conclusion: This study demonstrates that opicapone added to levodopa improves motor function and reduces MF without significantly enhancing dyskinesia intensity, along with a tolerable profile. Moreover, there were no differences regarding clinical improvement among PD phenotypes.
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