ReviewFrontiers in neurology
Interaction of brain endothelial cells with T cells: implications for progression and therapeutic strategies of multiple sclerosis.
Review in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dynamic interplay between brain endothelial cells (BECs) and T cells is a key event in the pathogenesis of multiple sclerosis (MS). This process allows the extravasation of T cells from the peripheral circulation into the central nervous system (CNS), thereby triggering neuroinflammation and tissue damage. In MS, activated BECs facilitate T cell activation, recruitment, and CNS infiltration by upregulating major histocompatibility complex (MHC) molecules, cell adhesion molecules (CAMs), and chemokines. In response, T cells interact with BECs by expressing corresponding ligands, thereby modulating the immunoregulatory and barrier functions of BECs. This cross-talk between BECs and T cells significantly increases the complexity of MS treatment. Therefore, this review systematically summarizes the mutually reinforcing interactions between BECs and T cells based on existing research and highlights recent therapeutic strategies for either BECs or T cells that show promise in achieving favorable outcomes for treating MS.
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