Trial reportJBMR plus2026
Upper arm administration is associated with higher injection site pain with romosozumab: a randomized controlled trial and a self-controlled study.
Trial report in JBMR plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
These 2 prospective studies investigated whether the injection site influences pain and local reactions with romosozumab treatment for osteoporosis. In Study 1, 169 patients were randomly assigned to receive monthly romosozumab 210 mg (2 vials) injections for 12 mo in either the abdomen (Abd group) or upper arm (Arm group). In Study 2, 55 patients received 105 mg (1 vial) injections in both sites to directly compare pain at each location. Pain was evaluated using a Visual Analog Scale (VAS, mm), and secondary outcomes included BMD, bone turnover markers (BTMs) (total P1NP and TRACP-5b), and injection site reactions (ISRs). In the randomized trial, 70 of 85 patients (82.4%) in the Abd group and 69 of 84 (82.1%) in the Arm group completed the study. The Arm group reported significantly greater pain than the Abd group, starting after the fifth injection (mean difference, 6.8 mm [95% CI, 0.7-12.8];
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