ArticleCureus2026
Opioid-Free Anesthesia for Mandibular Surgery in a Patient With Confirmed Opioid Hypersensitivity: A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Opioid-induced anaphylaxis is a rare but potentially life-threatening condition that represents a major challenge for perioperative pain management. We report the case of a 38-year-old woman with confirmed hypersensitivity to fentanyl and sufentanil, who underwent mandibular cyst resection under exclusive systemic opioid-free anesthesia. Following a previous aborted surgery due to an anaphylactic reaction during induction, allergy testing confirmed opioid hypersensitivity, while other intravenous anesthetics tested negative. Anesthesia was performed using a multimodal systemic approach combining dexmedetomidine, ketamine, lidocaine, magnesium sulfate, dexamethasone, and paracetamol, without regional anesthesia. Intraoperative hemodynamic parameters remained stable, and no allergic or anesthetic complications occurred. Postoperative pain was acceptable and managed with non-opioid analgesics, and patient satisfaction was high. This case highlights the feasibility of a fully systemic opioid-free anesthetic strategy in maxillofacial surgery for patients with confirmed opioid allergy.
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