ArticleCureus2026
Can Transcutaneous Vagus Nerve Stimulation be Effective After Rats' Spinal Cord Injury?
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMost spinal cord injuries (SCIs) result from trauma, and despite extensive research, no curative treatment exists. SCIs occur from primary and secondary injuries. The primary injury is caused by direct impact from the initial trauma, mechanical disruption, dislocation, stretch, compression, or ischemia involving the spinal cord. The primary injury leads to a secondary injury, characterized by the sequential progression of cell dysfunction and death, which begins with an influx of inflammatory cells and cytokines and ultimately results in apoptosis, necrosis, and gliosis. Thus, mitigating the neuroinflammatory process has been a key focus in treating further secondary injuries by multiple modalities, which include vagus nerve stimulation (VNS). The present project investigated the effect of transcutaneous VNS (t-VNS) on the inflammatory effects of SCI.
methodsThe histopathology of the SCI contusion model in male Sprague-Dawley rats was compared between groups that received t-VNS and those that did not.
resultNo statistical difference was found between SCI with and without t-VNS in M1, M2a, M2b, and M2c macrophages (all p>0.27). However, post-hoc correlations indicated M1 macrophages declined more rapidly over time in the t-VNS group. (Spearman r= -0.50; 95% CI: -0.78, -0.05).
conclusionsAlthough t-VNS did not significantly alter macrophage distribution, trends toward reduced M1 activation suggest a possible anti-inflammatory effect in the desired direction.
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