ReviewCureus2026
The Role of C-Terminal Crosslinking Telopeptide of Type II Collagen (CTX-II) After Anterior Cruciate Ligament Reconstruction: A Systematic Review.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anterior cruciate ligament (ACL) injuries are known to accelerate cartilage degradation and predispose patients to early-onset osteoarthritis. C-terminal cross-linked telopeptide of type II collagen (CTX-II), a biomarker of cartilage breakdown, can be detected in various body fluids, including urine, offering a non-invasive method for evaluating cartilage degeneration. This systematic review aimed to assess existing evidence on urinary CTX-II (uCTX-II) levels following ACL reconstruction (ACLR). A systematic search of two medical databases was conducted in accordance with PRISMA guidelines. Studies were screened for inclusion based on their assessment of CTX-II in human subjects undergoing ACLR, and methodological quality was evaluated using the Modified Coleman Methodology Score (MCMS). Four studies met the inclusion criteria, with methodological quality ranging from fair to good. However, the limited number of studies and variability in time points prevented consistent analysis of uCTX-II trends postoperatively. While current evidence is insufficient to establish temporal trends or reference ranges, uCTX-II remains a promising non-invasive biomarker for monitoring cartilage degradation in ACLR patients. These findings should be interpreted cautiously due to the limited number of studies, heterogeneity in study design and postoperative time points, and the restricted database search. Further longitudinal studies are needed to validate its clinical utility.
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