Predictors of Intensive Care Unit Outcomes Among Oncology Patients: A Retrospective Cohort Study at a Tertiary Referral Center in Saudi Arabia.

Background Caring for critically ill cancer patients is challenging due to the complexity of malignancy combined with acute organ dysfunction. Despite an increasing cancer burden in Saudi Arabia, data on intensive care unit (ICU) outcomes, particularly in the Najran region, remain limited. This study aims to identify clinical characteristics, ICU treatments, and mortality predictors in this population. Patients and methods This retrospective cohort study included 105 adult patients with active solid or hematologic malignancies admitted to the ICU at King Khalid Hospital, Najran, between January 2014 and February 2023. Data, including demographics, cancer details, ICU admission causes, treatments, and outcomes, were collected. Multivariate logistic regression was used to assess mortality predictors, and Kaplan-Meier analysis compared survival by disease stage. Results The cohort had a mean age of 56.8 ± 16.5 years, with 57 females (54.3%). Advanced-stage disease was present in 84 patients (80.0%), with gastrointestinal cancers being the most common primary site (35, 33.3%). Cancer-related complications accounted for 77 ICU admissions (73.3%). The median Sequential Organ Failure Assessment (SOFA) score at admission was 1.0 (interquartile range (IQR) 0.0-3.0). ICU mortality was 40 patients (38.1%), primarily due to cancer progression. Independent mortality predictors included older age (adjusted odds ratio (aOR) 1.04 per year; 95% CI 1.01-1.06), advanced-stage disease (aOR 3.37; 95% CI 1.56-7.26), respiratory infections (aOR 2.19; 95% CI 1.04-4.59), and higher SOFA scores (aOR 1.70 per point; 95% CI 1.28-2.27). The predictive model demonstrated good discrimination (optimism-corrected area under the curve (AUC) = 0.82). Kaplan-Meier analysis showed significantly lower 14-day survival in advanced-stage patients (41%) compared to non-advanced stage patients (78%; log-rank p < 0.001). Conclusions This study highlights high ICU mortality among cancer patients at a tertiary center in southwestern Saudi Arabia, particularly those with older age, advanced-stage disease, respiratory infections, and higher SOFA scores. Early identification of these high-risk predictors is essential to guide clinical decision-making, enhance infection control, and facilitate timely palliative care integration. These findings provide valuable regional data to inform critical care strategies for oncology patients in similar settings.