ReviewNeuropsychiatric disease and treatment2026
Clinical Features, Mechanisms, and Management of Anxiety in Youth with Tic Disorders: A Narrative Review.
Review in Neuropsychiatric disease and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The Association Between Depression and Tourette Syndrome: A Bibliometric Analysis of Research Hotspots and Emerging Trends from 2001 to 2025.Pediatric health, medicine and therapeutics · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tourette syndrome (TS) and related tic disorders (TD) are neurodevelopmental conditions primarily characterized by motor and vocal tics. However, coexistent anxiety has emerged as a pivotal yet under-recognized clinical determinant, at times overshadowing core tic symptomatology. This review delineates distinct anxiety phenotypes in youth with TD that differ from primary anxiety disorders. These specific presentations exert a profound impact on quality of life, adult outcomes, and socio-emotional functioning. By synthesizing recent literature, we highlight shared neurobiological substrates under this comorbidity, specifically focusing on aberrant connectivity within cortico-striato-thalamo-cortical (CSTC) circuits, dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and a shared genetic risk basis. Anxiety is not only a secondary symptom, but a component intertwined with the TD neurodevelopmental spectrum. The review advocate for integrated diagnosis and specific therapies to address the interplay between tics and anxiety, providing a clear framework to improve long-term psychosocial outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.