Evidence map›Paper›PMID 41798282›Full record

ArticleFrontiers in pediatrics2026

Factors associated with weaning success from prolonged mechanical ventilation in surviving Chinese pediatric intensive care units: a multicenter analysis.

Tian Li, Zhengzheng Zhang, Hong Ren, Chengjun Liu, Zihao Yang, Yibing Cheng, Wei Xu, Dong Qu, Hengmiao Gao, Furong Zhang and 7 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

17 authors.

Tian Li *Department of Pediatric Intensive Care Unit, National Children's Medical Center for South Central Region, Guangzhou Women and Children's Medical Center, Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zhengzheng Zhang *Department of Pediatric Intensive Care Unit, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
Hong RenDepartment of Pediatric Intensive Care Unit, National Children's Medical Center, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Chengjun LiuDepartment of Pediatric Intensive Care Unit, Western Pediatric Development Union, Children's Hospital of Chongqing Medical University, Chongqing, China.
Zihao YangDepartment of Pediatric Intensive Care Unit, National Clinical Research Center for Child Health, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Yibing ChengDepartment of Pediatric Intensive Care Unit, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Wei XuDepartment of Pediatric Intensive Care Unit, National Children's (Northeast) Regional Medical Center, Shengjing Hospital of China Medical University, Shenyang, China.
Dong QuDepartment of Pediatric Intensive Care Unit, Childre's Hospital, Capital Institute of Pediatrics, Beijing, China.
Hengmiao GaoDepartment of Pediatric Intensive Care Unit, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Furong ZhangDepartment of Pediatric Intensive Care Unit, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China.
Hongjun MiaoDepartment of Emergency/Critical Medicine, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Feng YeDepartment of Pediatric Intensive Care Unit, National Children's Medical Center for South Central Region, Guangzhou Women and Children's Medical Center, Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Musheng LiDepartment of Pediatric Intensive Care Unit, National Children's Medical Center for South Central Region, Guangzhou Women and Children's Medical Center, Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Jianping TaoDepartment of Pediatric Intensive Care Unit, National Children's Medical Center for South Central Region, Guangzhou Women and Children's Medical Center, Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Jianhui ZhangDepartment of Pediatric Intensive Care Unit, National Children's Medical Center for South Central Region, Guangzhou Women and Children's Medical Center, Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Li HuangDepartment of Emergency, National Children's Medical Centerr for South Central Region, Guangzhou Women and Children's Medical Center, Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Weiming ChenDepartment of Pediatric Intensive Care Unit, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To describe factors of ventilation strategies associated with weaning success for Methods: Conducted a retrospective study across eleven PICUs in mainland China from January 1, 2021, to December 31, 2022. Results: 234 patients diagnosed with PMV were included in the study. Weaning Outcomes: 58.1% (136 patients) successfully weaned, includeing 11.1% (26 patients) required only a tracheostomy. 9.8% (23 patients) needed non-invasive ventilation. 32. 1% (75 patients) continued to require mechanical ventilation. 34.2% (80 patients) on invasive pressure control mode at PMV diagnosis. Pressure control was the most commonly used method. Synchronized intermittent mandatory ventilation (SIMV) used by 30.4% (71 patients). Pressure support ventilation (PSV) used by 5. 1% (12 patients). 63.2% (148 patients) received physiotherapy. 44.9% (105 patients) received cough augmentation techniques. 26.9% (63 patients) underwent tracheostomy after an average of 29 days of invasive mechanical ventilation. Higher fraction of inspired oxygen (FiO2) on PMV diagnosis day associated with weaning failure, the OR value is 0.674. While lower airway diseases had one more times chance of weaning seccess than central nervous system diseases, the OR value is 2.144. Conclusion: Among survivors, ventilation strategies for PMV weaning in Chinese PICUs are diverse, with pressure control commonly used initially, followed by SIMV and PSV. We identified a higher FiO2 at PMV diagnosis as risk factors for weaning failure, while lower airway diseases were easier to wean.

Indexed as

childrendifficult weaninglong-term ventilationtracheostomyventilation strategies

Identifiers

PMID41798282
PMCPMC12963309

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.