ArticleResearch and practice in thrombosis and haemostasis2026
Normalization of activated partial thromboplastin time and diluted Russell's viper venom time ratios can be safely omitted in the assessment of lupus anticoagulant.
Article in Research and practice in thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Normalization of lupus anticoagulant (LA) ratios is recommended by both the Clinical & Laboratory Standards Institute and the International Society of Thrombosis and Hemostasis to reduce inter-assay and intra-assay variation. This study evaluates if the normalization step can be safely omitted. Methods: This retrospective observational study evaluated the diagnostic performance of non-normalized LA ratios. Anonymized patient data from routine clinical workflows were divided into 2 datasets: one for establishing optimal non-normalized cut-off values ( Results: Receiver operating characteristic analysis demonstrated high discriminative performance of non-normalized LA ratios for both dilute Russell's viper venom time (area under the curve 0.9818; 95% CI, 0.9462-1) and activated partial thromboplastin time (area under the curve 0.8926; 95% CI, 0.8077-0.9775). Youden's J identified optimal cut-off values of 1.304 for dilute Russell's viper venom time (95% CI, 1.297-1.307) and of 1.554 for activated partial thromboplastin time (95% CI, 1.504-1.562). Applying the above criteria to the validation dataset resulted in no reclassifications. Conclusion: The normalization step in the analysis of LA ratios can be safely omitted, allowing for a reduced laboratory workload, without affecting result interpretation and thus clinical outcomes.
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