SynthesisFrontiers in nutrition2025
The role of bovine colostrum in feeding intolerance in preterm neonates: a systematic review and meta-analysis of randomized controlled trials.
Synthesis in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Effects ofSexual medicine · 2026Review
- Immersive motor-cognitive virtual reality training for cognitive frailty: a systematic review and meta-analysis of randomized controlled trials.Frontiers in sports and active living · 2026Review
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Authors and funding
5 authors.
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Abstract
Background: Feeding intolerance is common in preterm infants and may lead to poor weight gain and prolonged hospitalization. Bovine colostrum, owing to its rich content of bioactive components such as immunoglobulins, lactoferrin, and growth factors, has been suggested to reduce feeding intolerance and promote gut maturation in preterm infants; however, available clinical trials provide inconsistent evidence regarding its efficacy. Therefore, this study aimed to conduct a systematic review and meta-analysis to evaluate the effects of bovine colostrum supplementation on feeding intolerance, necrotizing enterocolitis, and time to full enteral feeding in preterm infants. Method: We searched five databases for randomized controlled trials (RCTs) on bovine colostrum (BC) use in preterm neonates from their inception to 8 July 2025. Outcomes included feeding intolerance, necrotizing enterocolitis (NEC), and time to full enteral feeding to 120 mL/kg/d (TFF120). Data were analyzed using RevMan 5.3. Result: A total of four RCTs (670 infants) were included in this study. BC supplementation was associated with a lower incidence of feeding intolerance (RR = 0.76; 95% CI: 0.61-0.94) with low heterogeneity ( Conclusion: BC cannot be recommended for preterm infants based on current evidence. The observed reduction in feeding intolerance is likely due to performance bias, with no proven benefit for NEC or TFF120. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251102646, identifier CRD420251102646.
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