Evidence map›Paper›PMID 41798169›Full record

ArticleChemical engineering journal (Lausanne, Switzerland : 1996)2026

Targeted Photodynamic Therapy for Multispecies Dental Biofilms Using Liposome Encapsulated p-Toluquinone.

Chen Liang, Yongli Li, Zuan-Tao Lin, Zhilong Wang, Ya He, Yan Dong, Zihan Ran, Sophia Zhang, Ying Zhao, Songling Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical engineering journal (Lausanne, Switzerland : 1996), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chen LiangWellman Center for Photomedicine, Massachusetts General Hospital, Department of Dermatology, Harvard Medical School; 50 Blossom Street, Boston, MA 02114, US.
Yongli LiWellman Center for Photomedicine, Massachusetts General Hospital, Department of Dermatology, Harvard Medical School; 50 Blossom Street, Boston, MA 02114, US.
Zuan-Tao LinWellman Center for Photomedicine, Massachusetts General Hospital, Department of Dermatology, Harvard Medical School; 50 Blossom Street, Boston, MA 02114, US.
Zhilong WangWellman Center for Photomedicine, Massachusetts General Hospital, Department of Dermatology, Harvard Medical School; 50 Blossom Street, Boston, MA 02114, US.
Ya HeWellman Center for Photomedicine, Massachusetts General Hospital, Department of Dermatology, Harvard Medical School; 50 Blossom Street, Boston, MA 02114, US.
Yan DongWellman Center for Photomedicine, Massachusetts General Hospital, Department of Dermatology, Harvard Medical School; 50 Blossom Street, Boston, MA 02114, US.
Zihan RanWellman Center for Photomedicine, Massachusetts General Hospital, Department of Dermatology, Harvard Medical School; 50 Blossom Street, Boston, MA 02114, US.
Sophia ZhangWellman Center for Photomedicine, Massachusetts General Hospital, Department of Dermatology, Harvard Medical School; 50 Blossom Street, Boston, MA 02114, US.
Ying ZhaoDepartment of Stomatology, Xuanwu Hospital, Capital Medical University; No.45 Changchun Street, Xicheng District, Beijing, 100053, China.
Songling WangBeijing Laboratory of Oral Health, Capital Medical University, Beijing 100069, China.
Mei X WuWellman Center for Photomedicine, Massachusetts General Hospital, Department of Dermatology, Harvard Medical School; 50 Blossom Street, Boston, MA 02114, US.

Funding

Diagnosis, Treatment, and Monitoring of Polymicrobial Infections in Diabetic WoundsK01DK140529 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Yongli Li · 2024 to 2026
$469k
A novel bacteria-specific pro-photosensitizerR21AI183486 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI WU, MEI X · 2024 to 2025
$457k
NIAID NIH HHS R21 AI183486NIDDK NIH HHS K01 DK140529
6 · The paper itself

Abstract

Oral infections remain highly prevalent among individuals with limited access to routine dental care. Blue light (BL) offers a promising alternative for managing these infections, but its efficiency is limited without BL-activated photosensitizers. Here, we engineered an ionizable liposome to encapsulate a newly identified BL-activated photosensitizer, p-toluquinone (p-TQ). The resultant p-TQ@Lipo responded to the acidic pH produced by bacteria, facilitating the targeted delivery of the cargo to the pathogens. p-TQ@Lipo had a pH-dependent surface potential change from +29.5 ± 2.1 mV at pH=5, to +8.2 ± 0.1 mV at pH=7, and -6.4 ± 0.5 mV at pH=8. When combined with 405 nm BL at a fluence as low as 27 J/cm

Identifiers

PMID41798169
PMCPMC12962601

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.