ArticleJTO clinical and research reports2026
Histologic Grade 3 in Stage 1A Lung Adenocarcinoma: Survival Risks Comparable to Stage 1B.
Article in JTO clinical and research reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Biopsies Can Predict Lung Adenocarcinoma IASLC Grade: A New Proposal and Grading Pitfalls.JTO clinical and research reports · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Early stage NSCLC presents a significant risk of recurrence despite surgical resection. The International Association for the Study of Lung Cancer-proposed histologic grading system identifies high-grade tumors (≥20% solid, micropapillary, or complex glandular patterns) as a potential prognostic tool. This study evaluates the prognostic significance of histologic grade 3 within stage IA non-mucinous adenocarcinoma and its comparability to stage IB. Methods: We retrospectively analyzed 729 patients with stage I non-mucinous adenocarcinoma who underwent surgical resection (2010-2017). Tumors were graded per the International Association for the Study of Lung Cancer system. Kaplan-Meier survival curves and Cox proportional hazards models assessed overall survival (OS) and disease-free survival (DFS). Results: Stage IA grade 3 tumors demonstrated significantly worse OS and DFS compared with grade 1 and 2 tumors ( Conclusions: Histologic grade 3 in stage IA identifies high-risk tumors comparable to stage IB, highlighting its potential for refining staging criteria and guiding adjuvant therapy. Validation studies are needed to confirm these findings.
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