Evidence map›Paper›PMID 41798120›Full record

ArticleNeuro-oncology practice2026

The impact of neighborhood-level disadvantage on symptoms, mood, and health-related quality of life among the primary brain tumor population.

Zuena Karim, Kimberly Robins, Orieta Celiku, Yeonju Kim, Hope Miller, Elizabeth Vera, Jacqueline B Vo, Mark R Gilbert, Terri S Armstrong, Macy L Stockdill

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02851706 (Evaluation of the Natural History of and Specimen Banking for Patients With Tumors of the Central Nervous System), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02851706 completednot on this map

Evaluation of the Natural History of and Specimen Banking for Patients With Tumors of the Central Nervous System

TypeobservationalSponsorNational Cancer Institute (NCI)Ran2016 to 2025Enrolled1,214ConditionsBrain Cancer, Brain Tumor, Spine Cancer, Spine TumorArmsNo Treatment
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zuena KarimNeuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Kimberly RobinsNeuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Orieta CelikuNeuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Yeonju KimSchool of Medicine, Wayne State University, Detroit, MI, USA.
Hope MillerNeuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Elizabeth VeraNeuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0001-5990-7705
Jacqueline B VoRadiation Epidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, MD, USA.
Mark R GilbertNeuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Terri S ArmstrongNeuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0002-2414-0492
Macy L StockdillNeuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0002-6138-6002

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Evidence assessing the impact of neighborhood-level disadvantage and population density on outcomes of individuals with cancer is growing but has not been evaluated among the primary brain tumor (PBT) population. We evaluated associations of neighborhood-level disadvantage and population density with symptoms and health-related quality of life (HRQOL) among adults with a PBT. Methods: Neighborhood-level disadvantage, measured using the Area Deprivation Index (ADI), and population density were evaluated against symptoms (MDASI-BT and PROMIS Anxiety/Depression Short Forms v1.0 8a) using linear regression models and against HRQOL (EQ-5D-3L) using logistic regression models. Models were adjusted for age, sex, race/ethnicity, tumor grade, functional status, and tumor recurrence. Results were further stratified by tumor grade. Results: Of 643 participants, 24% lived in more disadvantaged neighborhoods, while 39% resided in non-urbanized areas. Patients in more disadvantaged neighborhoods reported greater symptom severity (β = 1.10, 95%CI [1.00, 1.20], Conclusion: Future studies should consider evaluating PBT symptoms with data on regional resources other than individual income as the next step to inform interventional work with under-represented and under-resourced populations.Trial Registration Number NCT#: NCT02851706.

Indexed as

health disparitiesneighborhood characteristicsprimary brain tumorssigns and symptoms

Identifiers

PMID41798120
PMCPMC12965653

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.