ArticleTurkish journal of chemistry2026
Development and optimization of a novel spectroscopic method to monitor crystallization behavior of BCS-II drug.
Article in Turkish journal of chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study investigated the crystallization behavior of dextromethorphan hydrobromide, a class II drug, to improve understanding of its supersaturation potential and formulation design. Conventional methods often lack the sensitivity or scalability needed for accurate detection of early nucleation events. To overcome these limitations, a novel process tracks real-time absorbance below turbidity levels to detect early molecular aggregation and phase separation. Crystallization kinetics of the drug was assessed at concentrations of 0.1, 0.2, and 0.3 mg/mL using three analytical techniques, namely, isothermal crystallization (baseline), ultraviolet (UV) absorbance (turbidity monitoring, UV-TM), and an optimized UV absorbance graphical method (UV-GM) (novel process). Induction times were recorded for each method, and statistical analysis was performed. In the descriptive statistics analysis, the one-sample test, and Pearson's correlation were applied to evaluate consistency, variance, and the strength of association (R
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