Evidence map›Paper›PMID 41798059›Full record

ArticleJHLT open2026

Preservation of pediatric donor hearts via subnormothermic machine perfusion: Comparison to cold storage.

Mitchell J Wagner, Guilherme Mainardi Aguiar da Silva, Sanaz Hatami, Mubashir Khan, Lily Lin, Xiuhua Wang, Tara Pidborochynski, Benjamin Adam, Jayan Nagendran, Jennifer Conway and 1 more

Abstract read
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In one paragraph

Article in JHLT open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mitchell J WagnerDepartment of Surgery, University of Alberta, Edmonton, Canada.
Guilherme Mainardi Aguiar da SilvaDepartment of Surgery, University of Alberta, Edmonton, Canada.
Sanaz HatamiDepartment of Surgery, University of Alberta, Edmonton, Canada.
Mubashir KhanDepartment of Surgery, University of Alberta, Edmonton, Canada.
Lily LinDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Xiuhua WangDepartment of Surgery, University of Alberta, Edmonton, Canada.
Tara PidborochynskiDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Benjamin AdamDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada.
Jayan NagendranDivision of Cardiac Surgery, Department of Surgery, University of Alberta, Edmonton, Canada.
Jennifer ConwayDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Darren H FreedDivision of Cardiac Surgery, Department of Surgery, University of Alberta, Edmonton, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ex-situ heart perfusion (ESHP) improves donor heart preservation via provision of a semi-physiologic, controlled environment. Optimizing preservation capacity through ESHP is of great interest to expand the donor pool and overcome logistical challenges. However, devices are currently untailored to pediatric donor hearts. We sought to evaluate subnormothermic ESHP (sESPH) in comparison to static cold storage (SCS). Methods: Juvenile Yorkshire pig hearts (∼20 kg) were procured and subject to 10 hours of sESHP ( Results: By echocardiography, hearts from both groups regained acceptable biventricular functionality, with no difference in left ventricular ejection fraction and shortening fraction between groups ( Conclusions: sESPH appears to prolong out-of-body time of pediatric donor hearts, with non-inferior tissue and functional preservation compared to SCS. sESHP may lessen inflammatory burden over the course of the preservation period.

Indexed as

Ex-vivoMachine perfusionPediatricSubnormothermicTransplantation

Identifiers

PMID41798059
PMCPMC12966762

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.