ArticleGynecology and minimally invasive therapy
Clinical Implications of Extracellular Vesicles in Endometriosis: A Systematic Review.
Article in Gynecology and minimally invasive therapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Robotic versus laparoscopic enucleation of ovarian endometriotic cysts with pathological analysis of inadvertent follicular loss.Journal of robotic surgery · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Endometriosis (EM) is a chronic gynecological condition characterized by the growth of endometrial-like tissue outside the uterus. Diagnosis has traditionally been challenging due to nonspecific symptoms and reliance on invasive procedures like laparoscopy. Recently, extracellular vesicles (EVs) have been implicated in EM pathogenesis, offering potential diagnostic and therapeutic applications. This study systematically reviews the role of EVs in EM. Materials and Methods: A Preferred Reporting Items for Systematic Reviews and Meta-analyses -guided systematic review was conducted. On March 3, 2024, PubMed, Medline, and Scopus were searched using the keywords "endometriosis" and either "extracellular vesicles," "EV," or "EVs," along with "treatment," "monitoring," or "diagnosis." The review included English-language original papers published between 2019 and 2024 focusing on EVs in EM. Studies on animals and those lacking direct references to EM were excluded from the study. Results: A total of 12 studies, comprising 657 patients, met the inclusion criteria. The studies examined EV cargo for diagnostic and therapeutic applications, with MicroRNAs (miRNAs) being the most frequently analyzed component. Five studies discussed miRNAs as potential diagnostic markers. EVs were also studied for their role in EM pathogenesis, including cell communication, immunomodulation, and angiogenesis. Conclusion: EVs show promise as noninvasive biomarkers for early-stage EM detection and management. Their involvement in disease pathogenesis suggests potential therapeutic applications. Identifying specific exosomal markers related to EM remains an active area of research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.