Evidence map›Paper›PMID 41797942›Full record

ArticleFrontiers in cellular and infection microbiology2025

The inflammasome next door: characterizing pyroptosis induction in HCV-infected and uninfected bystander cells

Hannah L Wallace, Cassandra L Gardner, Calvin N Ezeanyaegbu, Jordan Wight, Andrew S Lang, Rodney S Russell

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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hannah L WallaceImmunology and Infectious Diseases, Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St John's, NL, Canada.
Cassandra L GardnerImmunology and Infectious Diseases, Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St John's, NL, Canada.
Calvin N EzeanyaegbuImmunology and Infectious Diseases, Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St John's, NL, Canada.
Jordan WightDepartment of Biology, Faculty of Science, Memorial University, St John's, NL, Canada.
Andrew S LangDepartment of Biology, Faculty of Science, Memorial University, St John's, NL, Canada.
Rodney S RussellImmunology and Infectious Diseases, Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St John's, NL, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the fact that hepatitis C virus (HCV) can be cured with direct-acting antivirals in >95% of infected individuals, many of these individuals still have evidence of ongoing inflammation and some even go on to develop liver disease in the absence of ongoing infection. Previous work has demonstrated HCV-induced pyroptosis in both infected Huh-7.5 cells and uninfected bystander cells

Indexed as

Bystander EffectHepacivirusHepatitis CInflammasomesPyroptosisAnimalsCell LineCoculture TechniquesDEAD Box Protein 58HepatocytesHumansMacrophagesMonocytesTHP-1 CellsVirus ReplicationDEAD Box Protein 58Inflammasomeshepatitis C virus (HCV)hepatocytes (hepatocyte-like cells)immune cellsinflammationprogrammed cell death

Identifiers

PMID41797942
PMCPMC12960644

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.