Evidence map›Paper›PMID 41797928›Full record

ArticleiScience2026

Selective inhibition of ALDH1A3 impedes breast cancer growth and metastasis by blocking ALDH1A3-driven transcriptional programs.

Maya R MacLean, Bianca Laura Bernardoni, Wasundara Fernando, Giovanni Petrarolo, Ilaria D'Agostino, Cheryl A Dean, Jaganathan Venkatesh, Christopher S Hughes, Kerry B Goralski, Geetha Subramanian and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Maya R MacLeanDepartment of Pathology, Dalhousie University, Halifax, NS, Canada.
Bianca Laura BernardoniDepartment of Pathology, Dalhousie University, Halifax, NS, Canada.
Wasundara FernandoDepartment of Pathology, Dalhousie University, Halifax, NS, Canada.
Giovanni PetraroloDepartment of Pathology, Dalhousie University, Halifax, NS, Canada.
Ilaria D'AgostinoDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Cheryl A DeanDepartment of Pathology, Dalhousie University, Halifax, NS, Canada.
Jaganathan VenkateshDepartment of Pathology, Dalhousie University, Halifax, NS, Canada.
Christopher S HughesBiological Mass Spectrometry Core Facility, Dalhousie University, Halifax, NS, Canada.
Kerry B GoralskiBeatrice Hunter Cancer Research Institute, Halifax, NS, Canada.
Geetha SubramanianDepartment of Pathology, Dalhousie University, Halifax, NS, Canada.
Raj Pranap ArunDepartment of Pathology, Dalhousie University, Halifax, NS, Canada.
Hannah F CahillDepartment of Pathology, Dalhousie University, Halifax, NS, Canada.
Olivia L WalkerDepartment of Pathology, Dalhousie University, Halifax, NS, Canada.
Lynn N ThomasHistology and Digital Pathology Core Facility, Dalhousie University Halifax, Halifax, NS, Canada.
Robert C DouglasHistology and Digital Pathology Core Facility, Dalhousie University Halifax, Halifax, NS, Canada.
Concettina La MottaDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Paola MarcatoDepartment of Pathology, Dalhousie University, Halifax, NS, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aldehyde dehydrogenase 1A3 (ALDH1A3) promotes tumor growth, metastasis, and chemoresistance in multiple cancers, including triple-negative breast cancer (TNBC), yet no clinically approved, isoform-selective inhibitors exist. Here, we present CLM296, a novel, rationally designed, highly potent ALDH1A3 inhibitor. CLM296 exhibits nanomolar inhibition of ALDH1A3 in TNBC cells (half-maximal inhibitory concentration = 2 nM) with no off-target effects on ALDH1A1. Transcriptomic analysis shows that CLM296 selectively suppresses ALDH1A3-driven gene expression, confirming on-target activity. Functionally, CLM296 impedes ALDH1A3-mediated cell invasion

Indexed as

CancerMolecular interactionMolecular mechanism of gene regulation

Identifiers

PMID41797928
PMCPMC12962171

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.